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Magnolia Bark for Anxiety, Depression

Andrew Weil

Question: Can you tell me if magnolia bark is safe and effective for relief of anxiety and depression?

Answer: The bark of Magnolia oficinalis has been used in traditional Chinese medicine for centuries to address anxiety and nervous tension and to promote sleep. Some researchers believe that these effects are due to honokiol, a natural compound in the bark.

I discussed your question with Tieraona Low Dog M.D., director of The Fellowship at the Arizona Center for Integrative Medicine and an expert on botanical medicine. She told me that evidence is growing to support the traditional use of magnolia bark for improving sleep, lifting depression, and easing anxiety.

Most of this research is still in the basic science stage, but an Italian study published in February, 2011, compared a magnolia bark extract to soy isoflavones for treatment of anxiety, irritability and insomnia in menopausal women. The researchers found that the isoflavones effectively lessened the severity of classic menopausal symptoms, including hot flashes, while magnolia bark eased the participants' anxiety. Dr. Low Dog noted that an earlier study from Italy found that magnolia bark extract combined with magnesium improved sleep, mood, depression and anxiety in menopausal women.

If you're dealing with anxiety, I recommend a number of lifestyle changes that may help. Chief among them are practicing breathing exercises, particularly the relaxing breath, which I find to be reliable and effective. Other worthwhile measures include exercise, meditation, eliminating caffeine (from all sources), cognitive behavioral therapy, journaling and taking a "news fast" by avoiding the daily onslaught of (mostly bad) news online, on television and in newspapers and magazines.

For mild to moderate depression, I recommend exercise - 30 minutes a day. It is the most effective treatment I know. You can also try these other integrative recommendations for dealing with depression. For a full discussion of natural remedies for depression and an integrative plan for optimum emotional well-being, watch for my new book, Spontaneous Happiness, to be published by Little, Brown & Co. in November of this year.

Andrew Weil, M.D., is a world-renowned leader and pioneer in the field of integrative medicine, a healing oriented approach to health care which encompasses body, mind, and spirit.

Combining a Harvard education and a lifetime of practicing natural and preventive medicine, Dr. Weil is the founder and director of the Arizona Center for Integrative Medicine (AzCIM) at the University of Arizona Health Sciences Center, in Tucson, where he is also a Clinical Professor of Medicine and Professor of Public Health and the Lovell-Jones Professor of Integrative Rheumatology. Dr. Weil received both his medical degree and his undergraduate AB degree in biology (botany) from Harvard University.

Dr. Weil is an internationally-recognized expert for his views on leading a healthy lifestyle, his philosophy of healthy aging, and his critique of the future of medicine and health care. Approximately 10 million copies of Dr. Weil's books have been sold, including Spontaneous Healing and Why Our Health Matters.

Online, he is the editorial director of, the leading web resource for healthy living based on the philosophy of integrative medicine. He can be found on Facebook at, Twitter at, and Dr. Weil's Daily Health Tips blog at

Good info on many topics:
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