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What Are Migraine Injections and How Do They Work?

Migraine Injection

Did you know that migraine is the sixth most disabling illness in the world? A lot of people aren't aware of how incapacitating migraines can be, but those who suffer from them know the truth.

Getting rid of migraines long-term is not easy. Luckily, more research has been completed.

If you're looking for a solution for your acute or chronic migraine, this guide is for you. Read on to learn about migraine injections.

What Are Migraine Injections?

Migraine injections work to block the activity of CGRP to prevent or reduce the symptoms of a migraine. Doctors have learned that CGRP plays a role in getting migraines.

CGRP is found in the body and causes blood vessels to grow larger. Although this is not the only factor that can cause migraines, it is a focus for migraine injections.

How Do They Work?

Current injectable chronic migraine treatments block CGRP activity by sticking onto the protein or replacing where CGRP needs to go. Both of these solutions will leave CGRP inactive.

The four injections available for chronic migraine headaches are:

  • Vyepti (eptinezumab)
  • Aimovig (erenumab)
  • Ajovy (fremanezumab)
  • Emgality (galcanezumab)

Aimovig is the most unique injection among the four because it is the only one that sits where the CGRP usually goes, aka binds to the CGRP receptor. The other three options will directly bind to the CGRP.

Acute Migraine Treatment

Acute migraines are the most common term used for migraines that are not chronic. You may also hear it referred to as episodic migraine.

Those with acute migraines may experience the same symptoms like light sensitivity and sound sensitivity. However, they will have fewer migraines a month compared to a person with chronic migraines.

Injections for Acute Migraines

There are two injectable options for those with acute migraines that can treat pain as it happens. The two treatments are:

  • Sumatriptan (lmitrex)
  • Dihydroergotamine (DHE)

The four migraine injection treatments listed before are intended for regular use. Treatments for acute migraines are not supposed to be used daily or long-term.

These injections differ from the first four as they reduce pain by tightening blood vessels.

Administering Migraine Injections

If you wish to, you can administer migraine injections from the comfort of your home. Injections intended for long-term use can be used each month or every 90 days depending on the type you choose.

The injections will either come as a prefilled syringe or autoinjector. If you are afraid of needles, an autoinjector is the best option for you.

A prefilled syringe is less painful, but you don't have to see any needles when using an autoinjector. These devices are easy to use and often come with one push button.

If migraine injections don't seem right for you, see here for other headache relief options.

Can Migraine Injections Benefit You?

Anyone suffering from migraines, whether acute or chronic, knows how debilitating they can be. Migraine injections might be the solution you are looking for to help.

Before deciding on your own, it is best to speak to your primary care doctor.

Health is important which is why we write about it! Check out the other posts on our blog for more.


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